ÖZET

Obesity is an important factor in develpoments of IGT and Diabetes. This effect of obesity is realised through fat tissue as an endocrine organ. Adipose hormones are Leptin, Adiponectin, Resistin and TNF-a. These adipose hormones play an important role on insulin resistance and insulin resistance is practically the first step in developing Type 2 Diabetes. Recent studies show that weight reduction can prevent IGT even Type 2 Diabetes.