ÖZET
Amaç:
Bu çalışma güçlü bir antioksidan olan alfa lipoik asitin (ALA) endometriozis (EMS) üzerine etkilerini değerlendirmeyi amaçlamaktadır.
Yöntemler:
Otuz adet, 180-220 gram ağırlığında, seksüel matür, dişi Wistar albino rat üç gruba ayrılmıştır: Sham, EMS grubu ve EMS + ALA grubu. Deneysel EMS modeli oluşturulmadan ratlardan kan örnekleri alındı ve santrifüj edilerek -80 °C’de saklandı. EMS + ALA grubuna 15 gün, 50 mg/kg dozda, oral yoldan alfa lipoik asit verildi. Bu sürenin sonunda ratlarda tekrar kan örnekleri alındı ve santrifüj edilerek -80 °C’de saklandı. Bu örneklerden plazma total antioksidan status (TAS), plazma total oksidan status, oksidatif stres (OS) indeks ve kanser antijen 125 çalışıldı.
Bulgular:
Grupların başlangıç sonuçları arasında farklılık yoktu. İkinci alınan kan sonuçlarında sham grubu bütün parametrelerde, EMS + ALA grubu ise plazma TAS dışındaki bütün parametrelerde EMS grubundan istatiksel olarak farklıydı (p<0,05). Gruplarda parameterelerin 1.-15. gün değişimine baktığımızda ALA’nın olumlu etkilerini saptadık.
Sonuç:
ALA, EMS’de OS’yi azaltarak hastalığın şiddeti ve evresi üzerinde olumlu etki gösterebilir, ayrıca tedavi sonrası nüksleri azaltabilir.
Anahtar Kelimeler:
Endometriozis, oksidatif stress, alfa lipoik asit
Kaynaklar
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