E-ISSN: 2147-2688
The Relationship Between the Leptin and Vitamin D Levels in Postmenapausal Women
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Original Article
VOLUME: 56 ISSUE: 3
P: 213-217
September 2018

The Relationship Between the Leptin and Vitamin D Levels in Postmenapausal Women

Med Bull Haseki 2018;56(3):213-217
DOI: 10.4274/haseki.3831
Hakan Yavuzer 1
Afrodita Zeynep Taşkın 1
Filiz Demirdağ 1
İbrahim Murat Bolayırlı 2
Alper Döventaş 1
Deniz Suna Erdinçler 1
1. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, İstanbul, Türkiye
2. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 27.10.2017
Accepted Date: 22.01.2018
Publish Date: 20.09.2018
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ABSTRACT

Aim:

To determine the relationship of leptin with vitamin D and parathormone (PTH) levels in postmenopausal women who have no osteoporosis and to evaluate the effect of these three parameters on bone mineral dansity and bone homeostasis.

Methods:

Sixty-eight postmenopausal patients with no osteoporosis, who attended the general internal medicine, geriatric and endocrinology outpatient clinics between November 2013 and June 2014, were included in the study. The patients were divided into two groups according to vitamin D levels.

Results:

Group 1 consisted of 27 patients with low vitamin D levels and group 2 consisted of 41 patients with normal vitamin D levels. Two groups were similar in terms of age, age of menopause and body mass index (BMI). The mean PTH level and the mean leptin level in group 1 were statistically significantly higher than in group 2 (p= 0.01; p=0.01, respectively). There was no significant correlation between leptin and PTH in group 1 (r=0.16, p=0.4), however, a positive correlation was observed in group 2 (r=0.46, p=0.002). We found a significant positive correlation between leptin and BMI in both groups (r=0.40, p< 0.01). No significant correlation was found between leptin and vitamin D in both groups.

Conclusion:

In our study, the high leptin levels in postmenapasaul women having low vitamin D levels without osteoporosis or obesity may suggest the role of leptin in the prevention of osteoporosis.

References

1Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
2Gualillo O, Lago F, García M, et al. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology 1999;140:5149-53.
3Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M. Radioimmunoassay of leptin in human plasma. Clin Chem 1996;42:942-6.
4Scriba D, Aprath-Husmann I, Blum WF, Hauner H. Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes in primary culture via beta1- and beta2-adrenergic receptors. Eur J Endocrinol 2000;143:439-45.
5Berner HS, Lyngstadaas SP, Spahr A, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004;35:842-9.
6Gordeladze JO, Drevon CA, Syversen U, Reseland JE. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem 2002;85:825-36.
7Klein KO, Larmore KA, de Lancey E, Brown JM, Considine RV, Hassink SG. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endoc Metab 1998;83:3469-75.
8Thomas T, Burguera B, Melton LJ 3rd, et al. Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. Bone 2001;29:114-20.
9Roux C, Arabi A, Porcher R, Garnero P. Serum leptin as a determinant of bone resorption in healthy postmenopausal women. Bone 2003;33:837-52.
10Brabant G, Horn R, von zur Mühlen A, et al. Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia 2000;43;438-42.
11Ostlund RE Jr, Yang JW, Klein S, Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 1996;81:3909-13.
12Hollick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80(Suppl 6):1678-88.
13Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. J Am Board Fam Med 2009;22:698-706.
14Bordelon P, Ghetu MV, Langan RC. Recognition and management of vitamin D deficiency. Am Fam Physician 2009;80:841-6.
15Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080-6.
16Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004;79:362-71.
17Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES. Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab 1995;80:1118-23.
18Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197-207.
19Pogoda P, Egermann M, Schnell JC, et al. Leptin inhibits bone formation not only in rodents, but also in sheep. J Bone Miner Res 2006;21:1591-9.
20Matsunuma A, Kawane T, Maeda T, Hamada S, Horiuchi N. Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob mice. Endocrinology 2004;145:1367-75.
21Menendez C, Lage M, Peino R, et al. Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue. J Endocrinol 2001;170:425-31.
22Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-73.
23Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317-22.
24Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117:503-11.
25Fisher L, Fisher A. Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease. Clin Gastroenterol Hepatol 2007;5:513-20.
26Donahue SW, Galley SA, Vaughan MR, et al. Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis. J Exp Biol 2006;209:1630-8.
27Maetani M, Maskarinec G, Franke AA, Cooney RV. Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. Nutr Cancer 2009;61:225-31.
28Aypak C, Yıkılkan H, Dicle M, Önder Ö, Görpelioğlu S. Erişkin Obez Hastalarda D vitamini Düzeyinin Vücut Kitle İndeksi ile İlişkisi. Haseki Tıp Bülteni 2013;51:95-8.
29Matsunuma A, Horiuchi N. Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys 2007;463:118-27.
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