ABSTRACT

Introduction:

Theetiology of primarynocturnalenuresis (PNE) is multifactorial. Theeffects of geneticandhormonalfactors, sleepdisorders, andbladderdysfunctionhavebeenclaimed. Theotherfactorsincludeincreasedurineproduction at nightandimpairment of thecircadianrhythm of antidiuretichormone.

Aim:

Toinvestigaterenaltubularfunctions in childrenwith PNE.

Methods:

Fortypatientswith PNE wereincluded in thestudy. Urinedensity, FENa, FEK and TRP wereanalyzed in daytimeandnighttimeurine.

Results:

Themeannighttimeurinedensitywas 1020.12±7.38 andthemeandaytimeurinedensitywas 1013.20±7.11 (p<0.05). Therewasnosignificantdifferencebetweendaytimeandnighttimevalues of FENa (0.50±0.48 vs. 0.38±0.33), FEK (2.78±1.04 vs. 2.76±1.52) and TRP (88.5±2.4 vs 86.7±2.8) (p>0.05).

Conclusion:

Urinedensity in childrenwith PNE waslower at night. However, therewasnodifference in of FENa, FEK and TRP. Furtherstudiesareneeded in ordertoinvestigaterenaltubularfunctions in childrenwith PNE.