ABSTRACT
POEMS syndrome is classified in plasma cell dyscrasis and comes to clinic with neurolojic deficits. Its pathogenesis is unknown and it is a rare multisystemical disease. It takes less than 2 percent of the plasma cell dyscrasions. The five main findings rare polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin lesions. Polyneuropathy, Hepatosplenomegaly, lymphadenopathy, Primary hypothyroidi, Hypogonadism, IgA low Chain increase, hyperpigmentation, Femur head sclerotic lesion involving classical POEMS syndrome case and the literature related with the subject is given in the section below.
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