Distribution of the Rate of Morbidity and Mortality Developing After Surgical Treatment of Non-small Lung Cancer Surgery by Years
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Original Article
P: 166-174
June 2019

Distribution of the Rate of Morbidity and Mortality Developing After Surgical Treatment of Non-small Lung Cancer Surgery by Years

Med Bull Haseki 2019;57(2):166-174
1. İstanbul Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Cerrahisi Kliniği, İstanbul, Türkiye
2. İstinye Üniversitesi Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 13.09.2018
Accepted Date: 02.10.2018
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ABSTRACT

Aim:

The most effective treatment for lung cancer is surgery. Morbidity rates remained almost constant over the years. However, morbidity rates have started to decline with better management of preoperative and postoperative procedures. We examined the causes and results of postoperative morbidity and mortality after resection surgery by years.

Methods:

Anatomical lung resections performed in our clinic from January 2013 to December 2017 were retrospectively reviewed. Patients who underwent bilateral lung resections and those with comorbid infections, such as abscess and tuberculosis, were excluded.

Results:

A total of 907 patients were included in the study. 79% of the patients were male and the median age was 56 years. The increase in malignant pulmonary resection rates by years was statistically significant (p<0.001). It was found that video-assisted thoracoscopic surgery (VATS) lobectomy rates increased (p<0.001), thoracotomy lobectomy (p=0.006) and pneumonectomy rates decreased (p<0.001). The rates of atrial fibrillation, prolonged air leakage and pneumonia were statistically significantly decreased (p=0.004, p<0.001 and p<0.001, respectively) and no change was observed in mortality rates (p=0.123).

Conclusion:

Our study showed that postoperative morbidity was significantly reduced in lung cancer. A recent increase in VATS lobectomy procedures may have an effect on this result, however, the relationship was not statistically significant. Thus, the increase in the success rates can be attributed to the improved experience of the team in our hospital in years as well as being a specialty hospital for chest diseases and thoracic surgery.

References

1Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer2013;49:1374-403.
2Karapınar K, Aydoğmuş Ü, Cansever L, Kocatürk C, Saydam O, Bedirhan MA. Factors Affecting Postoperative Morbidity and Mortality in Patients Who Received Neoadjuvant Therapy for Lung Cancer. J Clin Anal Med 2015;6(suppl 3):299-302.
3Dieleman EMT, Uitterhoeve ALJ, van Hoek MW, et al. Concurrent daily Cisplatin and high dose radiotherapy in patients with stage III non-small cell lung cancer. Int J Radiat Oncol Biol Phys 2018;102:543-51.
4Tong S, Qin Z, Wan M, Zhang L, Cui Y, Yao Y. Induction chemoradiotherapy versus induction chemotherapy for potentially resectable stage IIIA (N2) non-small cell lung cancer: a systematic review and meta-analysis. J Thorac Dis 2018;10:2428-36.
5Kaiser D. Early and late postoperative complications in thoracic surgery interventions. Pneumologie 1991;45:147-52.
6Karamichalis JM, Putnam JB Jr, Lambright ES. Cardiovascular complications after lung surgery. Thorac Surg Clin 2006;16:253-60.
7Terzi A, Furlan G, Chiavacci P, Dal Corso B, Luzzani A, Dalla Volta S. Prevention of atrial tachyarrhythmias after non-cardiac thoracic surgery by infusion of magnesium sulfate. Thorac Cardiovasc Surg 1996;44:300-3.
8Bayliff CD, Massel DR, Inculet RI, et al. Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery.Ann Thorac Surg 1999;67:182-6.
9Jakobsen CJ, Bille S, Ahlburg P, Rybro L, Hjortholm K, Andresen EB. Perioperative metoprolol reduces the frequency of atrial fibrillation after thoracotomy for lung resection. J Cardiothorac Vasc Anesth 1997;11:746-51.
10Amar D, Roistacher N, Rusch VW, et al. Effects of diltiazem prophylaxis on the incidence and clinical outcome of atrial arrhythmias after thoracic surgery. J Thorac Cardiovasc Surg 2000;120:790-8.
11Lindgren L, Lepäntalo M, von Knorring J, Rosenberg P, Orko R, Scheinin B. Effect of verapamil on right ventricular pressure and atrial tachyarrhythmia after thoracotomy.Br J Anaesth 1991;66:205-11.
12Lanza LA, Visbal AI, DeValeria PA, Zinsmeister AR, Diehl NN, Trastek VF. Low-dose oral amiodarone prophylaxis reduces atrial fibrillation after pulmonary resection. Ann Thorac Surg 2003;75:223-30.
13Van Mieghem W, Coolen L, Malysse I, Lacquet LM, Deneffe GJ, Demedts MG. Amiodarone and the development of ARDS after lung surgery. Chest 1994;105:1642-5.
14Sayar A, Metin M, Ölçmen A, et al. Retorakotomiye Neden Olan PostoperatifKanamalar: Etyoloji, Tedavi ve Sonuçları. GKDC Dergisi 1998;6:342-6.
15Günlüoğlu MZ. Postoperatif Pulmoner Komplikasyonlar. Yücel O, Genç O, editörler. Journal of Clinical and Analytical Medicine Kitap Serisi, Akciğer Hastalıkları ve Tedavisi. DOI: 10.4328/JCAM.516.
16Kalaycı G, Dilege Ş. Akciğer Cerrahisi Sonrası Komplikasyonlar ve Tedavisi, Yüksel M, Kalaycı NG, editörler. Göğüs Cerrahisi. İstanbul: Özlem Grafik Matbaacılık; 2001. s 807-16.
17Wynne R, Botti M. Postoperative pulmonary dysfunction in adults after cardiac surgery with cardiopulmonary bypass: clinical significance and implications for practice. Am J Crit Care 2004;13:384-93.
18Reichert M, Pösentrup B, Hecker A, Padberg W, Bodner J. Lung decortication in phase 3 pleural empyema by video-assisted thoracoscopic surgery (VATS)-results of a learning curve study. J Thorac Dis 2018;10:4311-20.
19Işık H. Postoperatif Komplikasyonlar. Yücel O, Yıldızhan A, editörler. Göğüs Cerrahisi Cep Kitabı. Ankara. Merkez Repro Ltd. Şti; 2012.s.28-31.
20Clavero MJ, Cheyre EJ, Solovera EM, Aparicio PR. Transient diaphragmatic paralysis by continuous para-phrenic infusion of bupivacaine: a novel technique for the management of residual spaces. Ann Thorac Surg 2007;83:1216-8.
21Kılıçgün A,Gökçe M. Ameliyat Sonrası Görülen Komplikasyonlar. Ökten İ, Kavukçu HŞ, editörler. Göğüs Cerrahisi. 2. Baskı. İstanbul: Promat Basım Yayın; 2013. s.435-54.
22Sekine Y, Chiyo M, Iwata T, et al. Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Surg 2005;53:237-43.
23Karapinar K, Saydam O,Metin M, et al. Experience with Vacuum-Assisted Closure in the Management of Postpneumonectomy Empyema: An Analysis of Eight Cases. Thorac cardiovasc Surg 2016;64:258-62.
24Allen MS, Darling GE, Pechet TT, et al. ACOSOG Z0030 Study Group. Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg 2006;81:1013-9.
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