E-ISSN: 2147-2688
Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma
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Original Article
VOLUME: 53 ISSUE: 3
P: 229-236
September 2015

Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma

Med Bull Haseki 2015;53(3):229-236
DOI: 10.4274/haseki.2443
Selma Erdoğan Düzcü 1
Mihriban Gürbüzel 2
Saime Gül Barut 2
1. Bolu Abant İzzet Baysal Üniversitesi, İzzet Baysal Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, Bolu, Türkiye
2. Haseki Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İstanbul, Türkiye
No information available.
No information available
Received Date: 09.02.2015
Accepted Date: 18.04.2015
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ABSTRACT

Aim:

Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis. In this study, we investigated the relationships between the histopathologic parameters in the “Modified Scarff-Bloom-Richardson” microscopic grading and expression of p16 and bcl-2 gene in cases with invasive ductal carcinoma.

Methods:

We examined 88 patients who were diagnosed with invasive ductal carcinoma between 2011 and 2013 in Haseki Educational and Research Hospital Pathology Department. Immunohistochemical staining for p16 and bcl-2 was performed.

Results:

Increased expression of p16 gene was statistically significantly related with increased tubule formation, pleomorfism, mitosis rate and histological grade (p=0.008, p=0.001, p=0.005, and p<0.001, respectively). We found a statistically significant relationship of the rise of the expression of bcl-2 gene with decreased mitosis rate and histological grade (p=0.026 and p=0.024, respectively).

Conclusion:

As a result, it was observed that there was a positive correlation between parameters included in Modified Scarff-Bloom-Richardson grading system with p16 in addition to negative correlation with bcl-2 expression. p16 and bcl-2 are important prognostic biomarkers in human breast cancer.