ABSTRACT

In our study we compared the structure and functions of the heart between predialysis and hemodialysis patients and investigated the related factors.

This study included a total of 105 patients (mean age: 18-75 years): 51 on continuous hemodialysis and 54 predialysis subjects followed by the Nephrology Clinic and not yet involved in dialysis program. Laboratory data showing calcium-phosphorus metabolism disorders and transthoracic echocardiography results were evaluated.

Serum parathormone, phosphorus, calcium x phosphorus, alkaline phosphatase levels were significantly higher in the dialysis group compared to the predialysis group (p<0.001). No statistical difference was found between the groups with regard to median values of ejection fraction, mean values of left ventricular hypertrophy index and frequencies of diastolic dysfunction, and valve calcifications.

Since predialysis group had higher smoking rate (29.6%), low-density lipoprotein cholesterol levels [122 (100-148) mg/dL] and body mass index (27.6±3.8 kg/m2) and had been receiving systemic drugs in different ratios, the two groups were not similar regarding the traditional risk factors; thus, this may be the explanation for finding no statistical difference in echocardiographic parameters. Besides investigating all the factors involved in the pathogenesis of disease, echocardiographic evaluation should be done periodically in both predialysis and dialysis patients.