ABSTRACT

In this study, we aimed to compare meperidine and fentanyl for the postoperative patientcontrolled analgesia. After ethics commitee approval, 40 patients (ASA I-III categories), aged between 55 - 85 and prepared for total hip replacement were randomly allocated into two groups. All patients, receiving 5-7 mg/kg thiopental sodium for the induction of anaesthesia and receiving 0.2 mg/kg cis-atracurium for the muscle relaxation, were intubated orotrachealy. For the maintenance of anaesthesia all patients received %50 O2 - %50 N2O + % 0,5-1 isoflurane and we preferred remifentanyl infusion (0.1μg/kg) for the peroperative analgesia. At the end of the surgery 20μg/kg atropine and 40μg/kg neostigmine were applied to all patients for the decurarization. After the recovery period, the postoperative analgesia, group I received fentanyl (basal infusion 0.2μg/kg) and group II received meperidine (bazal infusion 0.1 mg/kg) with patient-controlled analgesia (PCA). PCA was applied for 48 hours. 1, 4, 12, 24 and 48 hours after the operation MAP, HR, VAS scores, sedation and comfort scales and the side effects were detected and recorded. There were no significant difference between groups regarding the MAP. In group I, HR at the 4th and 12th hours was lower than group II. At the 4th hour VAS score in group I was lower than in group II. There were no significant difference between groups regarding the side effects. In conclusion, we decided that meperidine and fentanyl appears to be effective and safe for the postoperative patient-controlled analgesia.