Original Article

Use of a Ketamine-Propofol Combination During Sedation and Analgesia


  • Gökçen Başaranoğlu
  • Asım Esen
  • Mefkur Bakan
  • Ufuk Topuz
  • Kadir İdin
  • Tarık Umutoğlu

Received Date: 15.05.2014 Accepted Date: 12.08.2014 Med Bull Haseki 2015;53(1):41-46


The aim of this study was to evaluate 1:1 mixture of ketamine and propofol for sedative/analgesic efficacy, patient comfort and postoperative complications.


The anesthesia and nursing records of patients who received ketamine-propofol mixture in Bezmialem Vakıf University Hospital between 2009 and 2010 were retrospectively documented.


Of the 51 adult patients who received ketamine-propofol sedation, 39 patients had ASA 1-2 score while 12 patients had ASA 3-4 score. No patient had apnea, desaturation, hypotension or vomiting. Two patients who had postoperative agitation received midazolam. All patients were transferred to the surgical ward when Aldrete scores were >8. Surgeon and patient satisfaction were high except in 2 patients.


Ketamine and propofol mixture for the purpose of sedation and analgesia is a practical method with minimal negative effects on respiration and hemodynamic variables, however, hallucination associated with ketamine may be observed. We conclude that due to the lack of hypnotic activity, 1/2 or 1/3 instead of 1/1 ketamine and propofol mixture would be more appropriate.

Keywords: Ketamine, propofol, ketofol, sedation, analgesia

Full Text (Turkish)