Aim:
Various crystalloid and colloidal solutions are used to prime the cardiopulmonary bypass (CPB) system. The aim of our study was to compare the effects of crystalloids and colloids used as priming solution during CPB.
Methods:
After the hospital scientific committee approval, informed consent was obtained from 40 patients undergoing elective coronary artery bypass grafting (CABG). The patients were prospectively randomized to group 1 (n=20) receiving crystalloid as priming volume and to group 2 (n=20) receiving colloid (20 ml/kg) 6% HES 130/0.4. Anaesthesia and CPB were standardized. Haemodynamic measurements were recorded. Laboratory parameters and plasma colloid osmotic pressures were measured.
Results:
Cardiac index was higher in colloid group than in crystalloid group after CPB. Plasma colloid osmotic pressure levels were lower in crystalloid group than in colloid group. Postoperative bleeding and renal function were similar in both groups.
Conclusion:
Crystalloids can be used as prime solution for effective haemodilution but they lack oncotic activity. In this study, we concluded that HES 130/0.4 has clinical efficiency and safety as a priming solution for CPB in adult patients.
Keywords: Cardiopulmonary bypass, priming solution, crystalloid, colloid