Original Article

A New Marker For Endothelial Function in Peritoneal Dialysis Patients: Apelin


  • Serhat Karadağ
  • Meltem Gürsu
  • Savaş Öztürk
  • Ahmet Gürdal
  • Filiz Basınoğlu
  • Zeki Aydın
  • Sami Uzun
  • Abdullah Sumnu
  • Eray Atalay
  • Hüseyin Oflaz
  • Rümeyza Kazancıoğlu

Received Date: 02.08.2012 Accepted Date: 19.10.2012 Med Bull Haseki 2013;51(1):5-10


The most important cause of death in end-stage renal disease is cardiovascular diseases (CVDs). Endothelial dysfunction (ED) is one of the most important steps in the pathogenesis of CVD Apelin is a peptide recently found to have important roles in cardiovascular and endothelial physiology; and we planned in our study to examine the relationship between apelin and endothelial functions in peritoneal dialysis (PD) patients.


Forty-two patients who were followed up in the PD unit at Haseki Training and Research Hospital were involved. Endothelial functions were evaluated ultrasonographically by flow-mediated dilation (FMD) test. Apelin levels and routine laboratory tests were studied from the blood samples obtained from the patients.


There was a negative correlation between apelin and FMD percentage (r=-0.334, p=0.03). FMD percentage positively correlated with triglyceride and very low density lipoprotein levels (r=0.310, p=0.046; r=0.304, p=0.05, respectively). FMD percentage significantly positively correlated with systolic and diastolic blood pressure (r=0.565,p=<0.001; r=0.560,p=<0.001, respectively). FMD was significantly lower patients with hypertension, compared to those without hypertension (9±5.8 vs. 14.9±6.6; p=0.01).


ED is closely related with hypertension and lipid profile in PD patients. Apelin may be used as a new marker for ED and a treatment alternative in PD patients.

Keywords: Apelin, endothelial dysfunction, peritoneal dialysis

Full Text (Turkish)