Case Report

A Case of Atypical (Cellular) Congenital Mesoblastic Nephroma Presenting with High Serum Levels of Neuron Specific Enolase in Neonatal Period


  • Nihan Hilal Hoşağası
  • Dilek Dilli
  • İsmet Faruk Özgüner
  • Gürses Şahin
  • Esin Cengiz Boduroğlu
  • Banu Aydın
  • Nuran Üstün
  • Ayşegül Zenciroğlu
  • Nurullah Okumuş
  • Burak Özkan

Received Date: 15.12.2013 Accepted Date: 04.02.2014 Med Bull Haseki 2014;52(3):223-226

The most common causes of abdominal mass are neuroblastoma, germ cell tumors, hepatoblastoma and congenital mesoblastic nephroma. Congenital mesoblastic nephroma (CMN) accounts for more than 90% of all renal tumors seen in the first three months of life. Total nephrectomy is curative. Neuron-specific enolase is a glycolytic enzyme that is localized primarily to the neuronal cytoplasm. Its sensitivity is especially high for neuroblastoma and small cell lung cancer. In this paper, we report a newborn with abdominal mass that was firstly considered as neuroblastoma due to calcifications observed on ultrasonography and high levels of serum neuron-specific enolase. After histopathological evaluation of the lesion, the patient was diagnosed as having atypical (cellular) congenital mesoblastic nephroma.

Keywords: Congenital mesoblastic nephroma, newborn

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