SummaryIn this study we aimed to compare the effects of TIVA and inhalation anaesthesia on hemodynamic parameters. After ethics comitee approval, 55 patients (ASA I-II), aged between 25-64, prepared for histerectomy operation were randomly allocated into two groups. Group I received 1-1.5μg/kg fentanyl, 2.5mg/kg propofol, group II received 1.5μg/kg fentanyl and %2-6 sevolurane via mask for the induction of anaesthesia. Endotracheal intubation was facilitated with 0.6mg/kg rocuronium i.v. in both groups. For the rest of the operation anaesthesia was maintained with propofol infusion in group I and sevoflurane %1-2 in group II. Preoperatively, before induction, at the induction time, during intubation, 2,4,8,13 minutes after induction, at the incision, during the operation, at the extubation time and 5 minutes after the extubation, for all patients SAP, DAP, MAP, HR and SpO2 were detected and recorded. In group II, SAP at the induction, 2, 8 minutes after the induction and 5 minutes after extubation were higher than group I. In group II, DAP 5 minutes after extubation was also higher than group I. In group II, HR preoperative, during the operation and 5 minutes after the extubation were higher than group I. There were no significiant difference between groups regarding the SpO2 values. Although the hemodynamic values at the induction and during the maintenance of anaesthesia were lower in propofol group, statistically there was no significiant difference between two groups. In conclusion, we decided that both of the anaesthesia methods (TIVA and inhalation anaesthesia) should be used safely for the induction and maintenance of anaesthesia.